The 60-year-old Clooney made the comments in an interview with Andrew Marr of the BBC.
"You're a friend of President Biden, you've known him for a long time. And looking at his poll numbers, which are really quite bad at the moment, things have gone wrong," Marr said. "What would you say about what's happened to the White House since he's taken over, and what's happened to America since he's taken over?"
"Well, I mean it's good, you know, you can't, it's like taking a battered child and thinking everything's going to be OK his first day in school. There's a lot of things that have to be repaired, there's a lot of healing that has to happen, and it's going to take time," Clooney replied.
"Poll numbers come up and go down, I would expect them to go back up again," he concluded.
Biden's poll numbers have continued to tumble since he entered office after a series of damaging incidents that have many questioning his ability to lead the country. Last week, the latest Quinnipiac poll found that only 38% of Americans gave Biden a positive approval rating, the lowest he has garnered since he entered the White House.